Jonny Lang started playing the guitar at the age of twelve, after his father took him to see the Bad Medicine Blues Band, one of the few blues bands in Fargo, North Dakota. Lang soon started taking guitar lessons from Ted Larsen, the Bad Medicine Blues Band's guitar player. Several months after Lang began, he joined the Bad Medicine Blues Band, which was then renamed Kid Jonny Lang & The Big Bang.
The band moved to Minneapolis, Minnesota and independently released the album Smokin' when Lang was fourteen. Lang was signed to A&M Records in 1996. He released the critically acclaimed multi-platinum Lie to Me on January 28, 1997. The next album, Wander this World was released on October 20, 1998 and earned a Grammy nomination. This was followed by the more soulful Long Time Coming on October 14, 2003. Lang also made a cover of Edgar Winter's "Dying to Live". Lang's album, the gospel influenced Turn Around, released in 2006 won him his first Grammy Award.
In more than ten years on the road, Lang has toured with the Rolling Stones, Buddy Guy, Aerosmith, B.B. King, Blues Traveler, Jeff Beck and Sting. In 1999, he was invited to play for a White House audience including President and Mrs. Clinton. Lang also makes a cameo appearance in the film Blues Brothers 2000 as a janitor. In 2004, Eric Clapton asked Lang to play a the Crossroads Guitar Festival to raise money for the Crossroads Centre Antigua.